Bioinformatics research on the SARS coronavirus (SARS_CoV) in China.
Identifieur interne : 003F64 ( Main/Exploration ); précédent : 003F63; suivant : 003F65Bioinformatics research on the SARS coronavirus (SARS_CoV) in China.
Auteurs : Pei Hao [République populaire de Chine] ; Min Chen ; Guoqing Zhang ; Weizhong He ; Yixue LiSource :
- Current pharmaceutical design [ 1873-4286 ] ; 2006.
Descripteurs français
- KwdFr :
- Biologie informatique, Chine (épidémiologie), Flambées de maladies, Génome viral, Hong Kong (épidémiologie), Humains, Modèles logistiques, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (génétique), Évolution moléculaire.
- MESH :
- génétique : Syndrome respiratoire aigu sévère, Virus du SRAS.
- épidémiologie : Chine, Hong Kong, Syndrome respiratoire aigu sévère.
- Biologie informatique, Flambées de maladies, Génome viral, Humains, Modèles logistiques, Évolution moléculaire.
- Wicri :
- geographic : République populaire de Chine, Hong Kong.
English descriptors
- KwdEn :
- China (epidemiology), Computational Biology, Disease Outbreaks, Evolution, Molecular, Genome, Viral, Hong Kong (epidemiology), Humans, Logistic Models, SARS Virus (genetics), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (transmission).
- MESH :
- geographic , epidemiology : China, Hong Kong.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus, Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome.
- Computational Biology, Disease Outbreaks, Evolution, Molecular, Genome, Viral, Humans, Logistic Models.
Abstract
Severe acute respiratory syndrome (SARS) first appeared in 2002 in China, which fastly affected about 8000 patients over 29 countries and caused 774 fatalities. As its pathogen was identified as a new kind of coronavirus (SARS_CoV), its genome was quickly sequenced on several isolates. Studies on its functional genomics were performed by combinatorial application of all the available bioinformatics tools and the development of new programs. In this way, it was found that the four proteins were absolutely responsible for nosogenesis of SARS, i.e. spike (S) protein; small envelop (E) protein; membrane (M) protein; and nucleocaspid (N) protein. Molecular evolution studies have revealed that SARS must be originated from wild animals, and it was demonstrated that the major genetic variations in some critical genes, particularly the Spike gene, was essential for the transition from animal-to-human transmission to human-to-human transmission. Theoretical models, either Logistic model or SIR model, were developed to describe the transmission of SARS. The recorded difference of SARS spreading in Beijing and Hong Kong was also reasonably analyzed according to these models. The whole process of fruitful bioinformatics studies, along with other related scientific investigations have set up an unprecedented paradigm for human of how to battle against sudden-breaking and catastrophic epidemics.
DOI: 10.2174/138161206779010404
PubMed: 17168762
Affiliations:
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first="Guoqing" last="Zhang">Guoqing Zhang</name></author><author><name sortKey="He, Weizhong" sort="He, Weizhong" uniqKey="He W" first="Weizhong" last="He">Weizhong He</name></author><author><name sortKey="Li, Yixue" sort="Li, Yixue" uniqKey="Li Y" first="Yixue" last="Li">Yixue Li</name></author></analytic><series><title level="j">Current pharmaceutical design</title><idno type="eISSN">1873-4286</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>China (epidemiology)</term><term>Computational Biology</term><term>Disease Outbreaks</term><term>Evolution, Molecular</term><term>Genome, Viral</term><term>Hong Kong (epidemiology)</term><term>Humans</term><term>Logistic Models</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute 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qualifier="génétique" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Hong Kong</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computational Biology</term><term>Disease Outbreaks</term><term>Evolution, Molecular</term><term>Genome, Viral</term><term>Humans</term><term>Logistic Models</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biologie informatique</term><term>Flambées de maladies</term><term>Génome viral</term><term>Humains</term><term>Modèles logistiques</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term><term>Hong Kong</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) first appeared in 2002 in China, which fastly affected about 8000 patients over 29 countries and caused 774 fatalities. As its pathogen was identified as a new kind of coronavirus (SARS_CoV), its genome was quickly sequenced on several isolates. Studies on its functional genomics were performed by combinatorial application of all the available bioinformatics tools and the development of new programs. In this way, it was found that the four proteins were absolutely responsible for nosogenesis of SARS, i.e. spike (S) protein; small envelop (E) protein; membrane (M) protein; and nucleocaspid (N) protein. Molecular evolution studies have revealed that SARS must be originated from wild animals, and it was demonstrated that the major genetic variations in some critical genes, particularly the Spike gene, was essential for the transition from animal-to-human transmission to human-to-human transmission. Theoretical models, either Logistic model or SIR model, were developed to describe the transmission of SARS. The recorded difference of SARS spreading in Beijing and Hong Kong was also reasonably analyzed according to these models. The whole process of fruitful bioinformatics studies, along with other related scientific investigations have set up an unprecedented paradigm for human of how to battle against sudden-breaking and catastrophic epidemics.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Min" sort="Chen, Min" uniqKey="Chen M" first="Min" last="Chen">Min Chen</name><name sortKey="He, Weizhong" sort="He, Weizhong" uniqKey="He W" first="Weizhong" last="He">Weizhong He</name><name sortKey="Li, Yixue" sort="Li, Yixue" uniqKey="Li Y" first="Yixue" last="Li">Yixue Li</name><name sortKey="Zhang, Guoqing" sort="Zhang, Guoqing" uniqKey="Zhang G" first="Guoqing" last="Zhang">Guoqing Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Hao, Pei" sort="Hao, Pei" uniqKey="Hao P" first="Pei" last="Hao">Pei Hao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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